Self-learning AI reveals NFL against the spread, over-under, money-line picks for each 2024 Week 2 game

The Week 2 NFL schedule is absolutely loaded, with high-profile NFL matchups including a battle of superstar quarterbacks when the Chiefs host the Bengals and a playoff rematch between the Lions and Buccaneers. This will be the sixth time that Joe Burrow and Patrick Mahomes have gone head-to-head in their careers and the Bengals will need to stand tall to avoid a disastrous 0-2 start. Burrow and the Bengals are 3-2 against the Chiefs and are also 3-2 against the spread during those games.

However, Kansas City has won and covered in the last two meetings. Which side of the NFL odds should you back in Chiefs vs. Bengals and Lions vs. Buccaneers, and what other Week 2 NFL spreads can you confidently target? Before you make any Week 2 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 2, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 2 NFL schedule here.

Top Week 2 NFL AI picks

After analyzing every game in Week 2, the AI PickBot says the Jaguars cover as 3.5-point favorites at home against the Browns. Jacksonville came out strong in Miami last week, taking a 17-7 lead into the half. However, Miami rallied to win on a field goal as time expired. The Jags limited the Dolphins to just 81 rushing yards in the loss and if they can force Cleveland to be similarly one-dimensional, it could pay off in a big way.

The Browns were walloped 33-17 by the Cowboys and Deshaun Watson had a miserable outing. He went 24-of-45 for 169 yards with two interceptions and was sacked six times. Cleveland went just 2-for-15 on third down in the loss. Those struggles are a big reason why the AI PickBot is rating the Jags as a B-rated pick against the spread. See its other Week 2 football predictions and football picks at SportsLine.

How to make Week 2 NFL picks

In addition, the AI PickBot has generated five A-rated picks for Week 2. You need to see the AI PickBot’s picks before making any Week 1 NFL bets of your own. You can only see it at SportsLine.

Who wins and covers each Week 2 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.